Despite my heavy computer use, I rarely experience hand or wrist pain. I consider myself fortunate. However, my mouse hand has been aching a bit lately. In light of my this, I decided it was time to change things up on the mouse front. I currently use the Logitech MX518 mouse at work and the Logitech G5 mouse at home. Both have the same roughly egg-like shape. I've never been completely satisfied with this shape, but it was the best of the available options at the time.
This is a companion discussion topic for the original blog entry at: http://www.codinghorror.com/blog/2007/04/mouse-dpi-and-usb-polling-rate.html